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Studies showed that it is selectively activated in hypoxic tumor regions, well tolerated at doses up to ~768 mg/m (weekly) or 1, 200 mg/m (every 21 days), with main side effects being mild fatigue, nausea, and blue skin/urine discoloration

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also suggested an increased risk of cholangiocarcinoma associated with the use of DPP-4 inhibitors and GLP-1 RAs, but the study involving GLP-1 RAs had a wide confidence interval, leading to some uncertainty in the conclusion ( Regarding the possible mechanisms of biliary diseases caused by these two types of drugs, existing studies have proposed multiple hypotheses