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NNMT is a metabolic enzyme that uses S-adenosyl methionine (SAM) as a methyl donor to methylate nicotinamide , producing 1-methylnicotinamide plus S-adenosyl homocysteine

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Problems with bodily absorption of the vitamin appear in 20% of people over 60 in the United States and United Kingdom according to research, and people with vegetarian or vegan diets are more likely to struggle with this condition

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