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Plaque doesn't take days off

The mechanism of action of tamoxifen cytotoxicity when used at concentrations above the nanomolar range has been linked to the induction of oxidative stress, through the engagement of ER -unrelated, undefined mediators that activate oxidative enzymes or modulate Ca 2+ homeostasis, increasing the intracellular levels of reactive oxygen species (ROS) or oxidized molecules (Lee et al., 2000

10.1038/nature12040 263 SousaC

GLP-1 medications work with the body's own appetite and blood-sugar signaling to reduce hunger and help you eat less without the constant battle

With Novo having already convinced regulators Wegovy can benefit the heart, other research on GLP-1 drugs is exploring their utility for conditions as varied as addiction and substance use disorders, anxiety, kidney disease, sleep apnea and Parkinsons.